Anticholinesterase Activity of Extracts and Isolated Coumarins from Roots of Ferulago blancheana, F. pachyloba, F. trachycarpa and F. bracteata

KARAKAYA S., KOCA M., Okuyucu M. B., Kilic C. S., ÖZBEK H., GÜVENALP Z., ...Daha Fazla

LATIN AMERICAN JOURNAL OF PHARMACY, cilt.37, sa.7, ss.1457-1462, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 7
  • Basım Tarihi: 2018
  • Dergi Adı: LATIN AMERICAN JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1457-1462
  • Anahtar Kelimeler: Anticholinesterase, Ferulago, felamidin, peucedanol-2 '-benzoate, prantschimgin, umbelliferone, ESSENTIAL OIL, IN-VITRO, ANTIOXIDANT, FRUITS, FURANOCOUMARINS, IDENTIFICATION, TURKEY, BOISS.
  • Gazi Üniversitesi Adresli: Evet

Özet

The study reports the anticholinesterase activities of Ferulago blancheana, F. pachyloba, F. trachycarpa and F. bracteata. Anticholinesterase activity from the methanol extracts from aerial parts and roots of these species and their n-hexane, dichloromethane, ethyl acetate, n-butanol and aqueous residue fractions along with the isolated compounds osthole (1), imperatorin (2), bergapten (3), prantschimgin (4), peucedanol-2'-benzoate (5), grandivitinol (6), suberosin (7), xanthotoxin (8), felamidin (9), marmesin (10), umbelliferone (11), and ulopterol (12) and a sterol mixture consisted of stigmasterol (13), beta-sitosterol (14) were evaluated by Ellman method. Dichloromethane fraction of root from F. blancheana showed strong inhibition against acetylcholinesterase (55.67%) and dichloromethane fraction of root from F. bracteata demonstrated strong inhibition against butyrlcholinesterase (99.78%) at 20 mu g/mL. Peucedanol-2'-benzoate (75.59%) and umbelliferone (61.09%) demonstrated strong inhibition against acetylcholinesterase. Prantschimgin (74.82%) and felamidin (77.11%) demonstrated strong inhibition against butyrlcholinesterase. Dichloromethane fractions of roots from these species had a notable anticholinesterase activities.