Akademik Veri Yönetim Sistemi
Oxidation Communications, cilt.35, sa.1, ss.128-137, 2012 (SCI-Expanded)
The aim of placebo-controlled double-blind study was to investigate the levels of oxidant and antioxidant biomarkers and lipids and to evaluate the effect of shortterm α-tocopherol supplementation (400 IU/day) on these parameters. In the groups who received α-tocopherol there was a significant increase in serum α-tocopherol concentrations (p<0.05). Plasma malondialdehyde levels of patient groups were significantly higher than those of control groups both before and after treatment. Plasma malondialdehyde levels decreased significantly after treatment. There was no statistical difference between case and control groups in terms of lipids. Cholesterol and LDLcholesterol levels decreased after treatment. While vitamins E and C concentrations in serum were lower in the patient group than the controls, there was no difference for β-carotene. They were found to be higher in the treatment group than in the patient group except vitamin C. These results support the presence of an oxidative activity and the possible preventive role of vitamin E therapy in patients with angina pectoris. In general, vitamin E supplementation caused an increase in antioxidant vitamins and a decrease in thiobarbituric acid reactive substances (TBARS) concentrations.