Radiation induced early necrosis in patients with malignant gliomas receiving temozolomide

Yaman E., Buyukberber S., Benekli M., Oner Y., Coskun U., AKMANSU M., ...Daha Fazla

CLINICAL NEUROLOGY AND NEUROSURGERY, cilt.112, sa.8, ss.662-667, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 112 Sayı: 8
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.clineuro.2010.05.003
  • Dergi Adı: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.662-667
  • Anahtar Kelimeler: Temozolomide, Early necrosis, Radiation, MRI spectroscopy, MAGNETIC-RESONANCE-SPECTROSCOPY, RECURRENT GLIOMA, MR SPECTROSCOPY, BRAIN-TUMORS, RADIOTHERAPY, PSEUDOPROGRESSION, GLIOBLASTOMA, INJURY, COMBINATION, DISTINCTION
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Temozolomide is the major drug in the treatment of malignant gliomas. Radiation induced necrosis can behave radiologically and clinically like a recurrent tumor. The major problem is the differentiation between recurrence and radiation injury especially in early phases of treatment. The aim of this study was to evaluate the patients receiving temozolomide showing early clinical or radiological progression and impact of early necrosis on follow-up.