The effect of apoprotein E gene polymorphism on neurocognitive functions of children with CHD

Demirdag T., GÜCÜYENER K., Soysal A. Ş., Ergun S. G., Ozturk Z., Ergun M. A., ...Daha Fazla

CARDIOLOGY IN THE YOUNG, cilt.33, ss.1556-1560, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1017/s1047951122002621
  • Dergi Adı: CARDIOLOGY IN THE YOUNG
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1556-1560
  • Anahtar Kelimeler: CHD, Apo E gene polymorphism, neurocognitive functions, neurodevelopmental outcome, CONGENITAL HEART-DISEASE, SCHOOL-AGED CHILDREN, NEURODEVELOPMENTAL OUTCOMES, APOLIPOPROTEIN-E, RISK-FACTORS, NEWBORNS, INFANTS
  • Gazi Üniversitesi Adresli: Evet

Özet

Studies have demonstrated an association between CHD and neurodevelopmental delay. This delay is associated with many factors like reduced blood flow and oxygen, cardiac catheterisations, and genetic factors. Apo E gene polymorphism is one of these genetic factors. This study aims to show the effect of Apo E gene polymorphism on neurodevelopmental process in children having CHD. A total of 188 children having CHD were admitted to the study. Apo E gene polymorphism of these patients was determined, and psychometric evaluation was performed. The relationship between psychometric test results and gene polymorphism was evaluated. This study shows that, similar to the literature, patients having cyanotic CHD have worse scores than acyanotic patients, and the children with CHD are under risk in terms of neuropsychiatric disorders. Other novel and important findings of this study were the lower verbal scores of epsilon 2 allele carriers than epsilon 4 carriers in Wechsler Intelligence Scale for Children-Revised group and the worse test score of patients having VSD than other acyanotic patients. Besides, some special disorders may be seen in this patient group.