Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica


Rahman A., Nasim S., Baig I., Jalil S., Orhan İ., Sener B., ...Daha Fazla

Journal of Ethnopharmacology, cilt.86, ss.177-180, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0378-8741(03)00055-2
  • Dergi Adı: Journal of Ethnopharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.177-180
  • Anahtar Kelimeler: Iris germanica L, Iridaceae, isoflavones, anti-inflammatory assay, COMPONENTS, IRIDALS, PLANTS, DRUGS
  • Gazi Üniversitesi Adresli: Evet

Özet

The anti-inflammatory activity of nine isoflavonoids 5,7-dihydroxy-3-(3′-hydroxy-4′,5′dimethoxy)-8- methoxy-4H-1-benzopyran-4-one 1, 5,7-dihydroxy-3-(3′-hydroxyl-4′, 5′-dimethoxy)-6-methoxy-4H-1-benzopyran-4-one 2, 5, 7-dihydroxy-3-(4′-hydroxy)-6-methoxy-4H-1-benzopyrane-4-one 3, 5-hydroxy-3-(4′-hydroxy)-6,7-methylenedioxy-4H-1-benzopyran-4-one 4, 5-hydroxy-3-(4′-methoxy)-6,7-methylenedioxy-4H-1-benzopyran-4-one 5, 5-methoxy-3-(4′-hydroxy)-6,7-methyenedioxy-4H-1-benzopyran-4-one 6, 5,7-dihydroxy-3-(3′-hydroxy-4′-methoxy)-6-methoxy-4H-1- benzopyran-4-one 7, 5,7-dihydroxy-3-(3′-methoxy-4′-hydroxy)-6-methoxy-4H-1- benzopyran-4-one 8, and isopeonol 9 determined by a spectrophotometric assay using the activated human neurtrophilis. These isoflavonoids were isolated from an important folkloric medicinal plant Irsa (Iris germanica L.), a member of the family Iridaceae. Structures of these compounds were identified by spectral comparison with the reported data and active members of this group adds into the growing number of non-steroidal anti-inflammatory agents. © 2003 Elsevier Science Ireland Ltd. All rights reserved.