Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica

Rahman A., Nasim S., Baig I., Jalil S., Orhan İ., Sener B., ...More

Journal of Ethnopharmacology, vol.86, pp.177-180, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 86
  • Publication Date: 2003
  • Doi Number: 10.1016/s0378-8741(03)00055-2
  • Journal Name: Journal of Ethnopharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.177-180
  • Keywords: Iris germanica L, Iridaceae, isoflavones, anti-inflammatory assay, COMPONENTS, IRIDALS, PLANTS, DRUGS
  • Gazi University Affiliated: Yes


The anti-inflammatory activity of nine isoflavonoids 5,7-dihydroxy-3-(3′-hydroxy-4′,5′dimethoxy)-8- methoxy-4H-1-benzopyran-4-one 1, 5,7-dihydroxy-3-(3′-hydroxyl-4′, 5′-dimethoxy)-6-methoxy-4H-1-benzopyran-4-one 2, 5, 7-dihydroxy-3-(4′-hydroxy)-6-methoxy-4H-1-benzopyrane-4-one 3, 5-hydroxy-3-(4′-hydroxy)-6,7-methylenedioxy-4H-1-benzopyran-4-one 4, 5-hydroxy-3-(4′-methoxy)-6,7-methylenedioxy-4H-1-benzopyran-4-one 5, 5-methoxy-3-(4′-hydroxy)-6,7-methyenedioxy-4H-1-benzopyran-4-one 6, 5,7-dihydroxy-3-(3′-hydroxy-4′-methoxy)-6-methoxy-4H-1- benzopyran-4-one 7, 5,7-dihydroxy-3-(3′-methoxy-4′-hydroxy)-6-methoxy-4H-1- benzopyran-4-one 8, and isopeonol 9 determined by a spectrophotometric assay using the activated human neurtrophilis. These isoflavonoids were isolated from an important folkloric medicinal plant Irsa (Iris germanica L.), a member of the family Iridaceae. Structures of these compounds were identified by spectral comparison with the reported data and active members of this group adds into the growing number of non-steroidal anti-inflammatory agents. © 2003 Elsevier Science Ireland Ltd. All rights reserved.