Real-life Data for Tenofovir Alafenamide Fumarate Treatment of Hepatitis B: the Pythagoras Cohort

Karasahin O., AKDEMİR KALKAN İ., Dal T., ALTUNIŞIK TOPLU S., Harputoglu M., Mete A. O., ...Daha Fazla

HEPATITIS MONTHLY, cilt.21, sa.2, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5812/hepatmon.104943
  • Dergi Adı: HEPATITIS MONTHLY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database
  • Anahtar Kelimeler: Bone Mineral Density, Hepatitis B, Chronic Hepatitis B, Glomerular Filtration Rate, Tenofovir Alafenamide, Real Life, Tenofovir Disoproxil
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Chronic hepatitis B (CHB) is a viral infection that can result in life-threatening conditions, such as hepatocellular carcinoma and cirrhosis. Tenofovir, which is used for the treatment of CHB, is a nucleotide analog that inhibits HBV-DNApolymerase and has two formulations: disoproxil and alafenamide. In contrast to tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF) penetrates the whole hepatocyte without being eliminated due to its longer plasma half-life and greater plasma stability. As a result, side effects such as proximal renal tubulopathy and loss of bone density are less common in the treatment of TAF and have similar efficacy to TDF.