Recent Trends in Hydrogel-Based Biosensor Technology for the Diagnosis of Neurodegenerative Diseases

Ayçiçek S., COŞKUN CEVHER Ş., ACAR S.

ACS Applied Bio Materials, cilt.8, sa.7, ss.5424-5444, 2025 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 8 Sayı: 7
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1021/acsabm.5c00420
  • Dergi Adı: ACS Applied Bio Materials
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, Compendex, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.5424-5444
  • Anahtar Kelimeler: biomarkers, biosensor, challenges, design, detection, hydrogels, neurodegenerative diseases
  • Gazi Üniversitesi Adresli: Evet

Özet

Early diagnosis of neurodegenerative diseases is essential for the development of appropriate treatment strategies. Current diagnostic methods have a number of limitations and challenges. Alternative biomaterials such as hydrogels are potential candidates that are attracting attention in the design process of biosensors for the diagnosis of neurodegenerative diseases. Three-dimensional networks of cross-linked hydrophilic polymers, known as hydrogels, have characteristics that are comparable to those of biological tissues. The integration of hydrogels into biosensor designs for the diagnosis of neurodegenerative diseases offers functionality and structural advantages. This review summarizes recent trends in hydrogel-based biosensors for the detection of neurodegenerative diseases, their design, applications, as well as a comprehensive overview of their advantages and disadvantages.