Pre-transplant sTIM-3 levels may have a predictive impact on transplant outcome in acute leukemia patients

YEGİN Z. A. , Can F., Aydin Kaynar L., GÖKÇEN S., Eren Sadioglu R., ÖZKURT Z. N. , ...More

HEMATOLOGY, vol.25, no.1, pp.125-133, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1080/16078454.2020.1738097
  • Journal Name: HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.125-133
  • Keywords: TIM-3, acute myeloid leukemia, acute lymphoblastic leukemia, allogeneic hematopoietic stem cell transplantation, graft versus host disease, viral hemorrhagic cystitis, prognosis, cytogenetics, VERSUS-HOST-DISEASE, CONSENSUS DEVELOPMENT PROJECT, ACUTE MYELOID-LEUKEMIA, PLASMA BIOMARKERS, NEUTROPENIC PATIENTS, EUROPEAN CONFERENCE, CLINICAL-TRIALS, STEM-CELLS, T-CELLS, TIM-3


Objectives:T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3) is considered as a negative regulator of T-cell driven immune response. This study is planned to investigate the prognostic role of pre-transplant soluble TIM-3 (sTIM-3) levels in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients.Methods:Pre-transplant serum sTIM-3 levels were measured in 177 allo-HSCT recipients [median age: 36(16-66) years; male/female: 111/66].Results:Pre-transplant sTIM-3 levels were significantly higher in acute myeloid leukemia (AML) patients compared to acute lymphoblastic leukemia (ALL) patients (p = 0.01). Pre-transplant sTIM-3 levels were significantly lower in patients with abnormal cytogenetics (p = 0.017). Pre-transplant sTIM-3 levels were significantly higher in patients who developed viral hemorrhagic cystitis (p = 0.034). A positive correlation was demonstrated between sTIM-3 levels and acute graft versus host disease (GvHD) grade (p = 0.013;r = 0.299). Overall survival (OS) was not statistically different between low- and high-TIM-3 groups (%35.2 vs %20.4;p > 0.05). Primary diagnosis (p = 0.042), sinusoidal obstruction syndrome (p < 0.001), acute GvHD (p = 0.001), chronic GvHD (p = 0.009) and post-transplant relapse (p = 0.003) represented significant impact on OS.Discussion:Increased sTIM-3 levels in AML patients seem to be compatible with the previous reports. The inhibitor role of TIM-3 in cellular immune response may be a possible explanation for the association of sTIM-3 with viral infections and GvHD. However, the main challenge remains to be the ambiguous association of pre-transplant sTIM-3 levels and post-transplant complications, as allo-HSCT recipients are expected to represent donor genetic features in the post-transplant setting.Conclusion:Further studies are warranted to clarify the particular role of sTIM-3 in the allo-HSCT setting.