Chlorpyrifos Induced Cardiotoxicity in Rats and the Protective Role of Quercetin and Catechin

BAŞ H., KALENDER Y.

GAZI UNIVERSITY JOURNAL OF SCIENCE, cilt.24, sa.3, ss.387-395, 2011 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2011
  • Dergi Adı: GAZI UNIVERSITY JOURNAL OF SCIENCE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.387-395
  • Anahtar Kelimeler: Chlorpyrifos, Flavonoids, Antioxidant Enzymes, Histopathology, Heart, INDUCED OXIDATIVE STRESS, FREE-RADICAL METABOLISM, VITAMINS C, LIPID-PEROXIDATION, ENDOGENOUS ANTIOXIDANTS, TESTICULAR TOXICITY, HUMAN ERYTHROCYTES, EXPOSURE, ENZYMES, TISSUES
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study, chlorpyrifos, catechin, quercetin and catechin- or quercetin+chlorpyrifos were given to Wistar rats for 4 weeks. Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase ( SOD) and catalase (CAT); decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in heart compared to the control. In catechin- and quercetin+chlorpyrifos groups, we observed the protective effects of flavonoids on examining parameters. Light microscopic investigations revealed that chlorpyrifos induced histopathological alterations in heart. Milder histopathological changes were observed co-treated with catechin-or quercetin+chlorpyrifos. As a result, catechin and quercetin significantly reduce chlorpyrifos induced cardiotoxicity in rats, but they aren't protect completely.