Clozapine-induced myoclonic seizures and valproic acid

Taner E., COŞAR B., Işik E.

International Journal of Psychiatry in Clinical Practice, vol.2, no.1, pp.53-55, 1998 (SCI-Expanded) identifier identifier


Within a 3-year period, in 220 patients receiving clozapine, we observed myoclonic seizures in two who had no previous epileptic history. Seizures appeared at the titration phase at relatively low doses, and resolved with the addition of valproic acid, allowing further increases of the clozapine dose to therapeutic levels.