Synthesis of 2-(2-benzimidazolyl)/2-(2-benzothiazolyl)-5-alkyl/aryl-1,2 dihydro-3H-pyrazol-3-one derivatives and their antifungal activities

Tosun, A.; Gok, S.; ŞAHİN, MELEK; Ersan, SEYHAN; BAYTAŞ, SULTAN; Uzunoglu, S.; Abbasoglu, UFUK

Synthesis of 2-(2-benzimidazolyl)/2-(2-benzothiazolyl)-5-alkyl/aryl-1,2 dihydro-3H-pyrazol-3-one derivatives and their antifungal activities

Tosun A., Gok S., ŞAHİN M. G., Ersan S., BAYTAŞ S., Uzunoglu S., ...Daha Fazla

Gazi Universitesi Eczacilik Fakultesi Dergisi, cilt.12, sa.2, ss.145-152, 1995 (Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 12 Sayı: 2
Basım Tarihi: 1995
Dergi Adı: Gazi Universitesi Eczacilik Fakultesi Dergisi
Derginin Tarandığı İndeksler: Scopus
Sayfa Sayıları: ss.145-152
Anahtar Kelimeler: 1,2-dihydro-3H-pyrazol-3-ones, 2-(pyrazol-3-one-2-yl)benzimidazo les, 2-(pyrazol-3-one-2-yl)benzothiazoles, antifungal activities, IR and NMR spectral data
Gazi Üniversitesi Adresli: Evet

Özet

Seven 1,2-dihydro-3H-pyrazol-3-one derivatives carrying 2-benzothiazolyl- and 2-benzimidazolyl-substituents at position 2 have been synthesized. Their structures have been elucidated by using elemental analyses and their spectral data. Antifungal activity of the compounds investigated against four yeast-like fungi (Candida albicans, Candida stellatoidea, Candida parapsilosis, Candida pseudotropicalis) using rabenzazole and clotrimazole as references. The benzimidazole derivatives have been found more potent than benzothiazole congeners in general.