Circulating Kisspeptin and Klotho Levels in Women with Hyperprolactinemia


Arslan I. E., Ozturk B. O., Bolayir B., YALÇIN M. M., YETKİN İ., AKTÜRK M. Y.

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, vol.26, no.3, pp.115-119, 2022 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.5152/tjem.2022.22068
  • Journal Name: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.115-119
  • Keywords: Hyperprolactinemia, kisspeptin, klotho, neurokinin B, pituitary, HORMONE-SECRETION, ARCUATE NUCLEUS, PROLACTIN, NEURONS, EXPRESSION, RELEASE, OBESITY, KISS-1
  • Gazi University Affiliated: Yes

Abstract

Objective: Kisspeptin is a neuropeptide that acts mainly on gonadotropin-releasing hormone in the hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance in recent years. Klotho is an anti-aging transmembrane glycoprotein with growth hormone and insulin-like growth factor-1-related effects. Both kisspeptin and klotho seem to interact with prolactin in the hypothalamic-pituitary region. In this study, we aimed to investigate the relationship between hyperprolactinemia and circulating kisspeptin and klotho levels.