TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, cilt.26, sa.3, ss.115-119, 2022 (ESCI)
Objective: Kisspeptin is a neuropeptide that acts mainly on gonadotropin-releasing hormone in the hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance in recent years. Klotho is an anti-aging transmembrane glycoprotein with growth hormone and insulin-like growth factor-1-related effects. Both kisspeptin and klotho seem to interact with prolactin in the hypothalamic-pituitary region. In this study, we aimed to investigate the relationship between hyperprolactinemia and circulating kisspeptin and klotho levels.