Circulating Kisspeptin and Klotho Levels in Women with Hyperprolactinemia


Arslan I. E. , Ozturk B. O. , Bolayir B., YALÇIN M. M. , YETKİN İ., AKTÜRK M. Y.

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, vol.26, no.3, pp.115-119, 2022 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.5152/tjem.2022.22068
  • Journal Name: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.115-119
  • Keywords: Hyperprolactinemia, kisspeptin, klotho, neurokinin B, pituitary, HORMONE-SECRETION, ARCUATE NUCLEUS, PROLACTIN, NEURONS, EXPRESSION, RELEASE, OBESITY, KISS-1
  • Gazi University Affiliated: Yes

Abstract

Objective: Kisspeptin is a neuropeptide that acts mainly on gonadotropin-releasing hormone in the hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance in recent years. Klotho is an anti-aging transmembrane glycoprotein with growth hormone and insulin-like growth factor-1-related effects. Both kisspeptin and klotho seem to interact with prolactin in the hypothalamic-pituitary region. In this study, we aimed to investigate the relationship between hyperprolactinemia and circulating kisspeptin and klotho levels.