Role of serum toll-like receptors 2 and 4 in non-alcoholic steatohepatitis and liver fibrosis

Cengiz M., Ozenirler S., Elbeg S.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.30, sa.7, ss.1190-1196, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 7
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/jgh.12924
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1190-1196
  • Anahtar Kelimeler: NASH, non-invasive marker, toll-like receptors, HEPATOCELLULAR-CARCINOMA, SOLUBLE FORMS, DISEASE, PATHWAY, OBESITY, MARKER
  • Gazi Üniversitesi Adresli: Evet

Özet

Background and AimNon-alcoholic fatty liver disease is a common cause of chronic liver disease, including non-alcoholic steatohepatitis (NASH). Our aim was to investigate whether serum toll-like receptors 2 and 4 (TLR2 and TLR4) levels are correlated with NASH and able to predict liver fibrosis, as well as to compare these markers with other non-invasive fibrosis scores (aspartate aminotransferase [AST] to alanine aminotransferase ratio, AST to platelet ratio index, fibrosis index, fibrosis 4, and fibrosis cirrhosis index).