Oxidized low-density lipoprotein levels and carotid intima-media thickness as markers of early atherosclerosis in prepubertal obese children


OKUR İ., TÜMER L., EZGÜ F. S. , Yesilkaya E., Aral A., ÖZHAN OKTAR S., ...More

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.26, pp.657-662, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26
  • Publication Date: 2013
  • Doi Number: 10.1515/jpem-2012-0374
  • Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.657-662
  • Keywords: carotid IMT, oxidized LDL, prepubertal obesity, CARDIOVASCULAR RISK-FACTORS, AMBULATORY BLOOD-PRESSURE, ENDOTHELIAL DYSFUNCTION, INSULIN-RESISTANCE, CHILDHOOD OBESITY, FAMILIAL HYPERCHOLESTEROLEMIA, HEALTHY POPULATION, METABOLIC SYNDROME, ADOLESCENT GIRLS, TURKISH CHILDREN
  • Gazi University Affiliated: Yes

Abstract

Objectives: Children with obesity have a high cardiovascular risk and an impaired oxidant-antioxidant status, which may lead to endothelial dysfunction and increased carotid intima media thickness (IMT) even in childhood. The aim of this study was to investigate the circulating oxidized low-density lipoprotein (LDL) concentrations and the IMT of carotid arteries in prepubertal obese children, and also to search for its possible association with carotid atherosclerosis.