Retrospective analysis of the association of the expression and single nucleotide polymorphisms (SNPs) of the TLR4, PTX3 and Dectin-1 (CLEC/A) genes with development of invasive aspergillosis among haematopoietic stem cell transplant recipients with oncohaematological disorders
MYCOSES, cilt.63, ss.832-839, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63
- Basım Tarihi: 2020
- Doi Numarası: 10.1111/myc.13087
- Dergi Adı: MYCOSES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.832-839
- Anahtar Kelimeler: Dectin-1 (CLEC/A), invasive aspergillosis, PTX3, RNA expression analyses, single nucleotide polymorphisms, stem cell transplant recipients, TLR4, PULMONARY ASPERGILLOSIS, FUNGAL-INFECTIONS, HUMAN DECTIN-1, SUSCEPTIBILITY, PROMOTER, RECOGNITION, DEFICIENCY, RECEPTORS, DISEASE, RISK
- Gazi Üniversitesi Adresli: Evet
Özet
Objectives Several studies described single nucleotide polymorphisms (SNPs) on pattern recognition receptor (PRR) such as toll-like receptors (TLRs), dendritic cell-associated C-type lectin-1 (Dectin-1/CLEC7A) genes of patients with invasive fungal infections (IFIs) caused by Candida and Aspergillus. We screened TLR4, Dectin-1 and PTX3 polymorphisms in a Turkish population with invasive aspergillosis (IA) underlying haematological malignancies.