Retrospective analysis of the association of the expression and single nucleotide polymorphisms (SNPs) of the TLR4, PTX3 and Dectin-1 (CLEC/A) genes with development of invasive aspergillosis among haematopoietic stem cell transplant recipients with oncohaematological disorders

Kalkancı A., Tuğ E., Fidan I., Güzel Tunçcan Ö., Özkurt Z. N., Yegin Z. A., ...Daha Fazla

MYCOSES, cilt.63, ss.832-839, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1111/myc.13087
  • Dergi Adı: MYCOSES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.832-839
  • Anahtar Kelimeler: Dectin-1 (CLEC/A), invasive aspergillosis, PTX3, RNA expression analyses, single nucleotide polymorphisms, stem cell transplant recipients, TLR4, PULMONARY ASPERGILLOSIS, FUNGAL-INFECTIONS, HUMAN DECTIN-1, SUSCEPTIBILITY, PROMOTER, RECOGNITION, DEFICIENCY, RECEPTORS, DISEASE, RISK
  • Gazi Üniversitesi Adresli: Evet

Özet

Objectives Several studies described single nucleotide polymorphisms (SNPs) on pattern recognition receptor (PRR) such as toll-like receptors (TLRs), dendritic cell-associated C-type lectin-1 (Dectin-1/CLEC7A) genes of patients with invasive fungal infections (IFIs) caused by Candida and Aspergillus. We screened TLR4, Dectin-1 and PTX3 polymorphisms in a Turkish population with invasive aspergillosis (IA) underlying haematological malignancies.