Retrospective analysis of the association of the expression and single nucleotide polymorphisms (SNPs) of the TLR4, PTX3 and Dectin-1 (CLEC/A) genes with development of invasive aspergillosis among haematopoietic stem cell transplant recipients with oncohaematological disorders

Kalkancı A., Tuğ E., Fidan I., Güzel Tunçcan Ö., Özkurt Z. N. , Yegin Z. A. , ...More

MYCOSES, vol.63, pp.832-839, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63
  • Publication Date: 2020
  • Doi Number: 10.1111/myc.13087
  • Journal Name: MYCOSES
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.832-839
  • Keywords: Dectin-1 (CLEC/A), invasive aspergillosis, PTX3, RNA expression analyses, single nucleotide polymorphisms, stem cell transplant recipients, TLR4, PULMONARY ASPERGILLOSIS, FUNGAL-INFECTIONS, HUMAN DECTIN-1, SUSCEPTIBILITY, PROMOTER, RECOGNITION, DEFICIENCY, RECEPTORS, DISEASE, RISK


Objectives Several studies described single nucleotide polymorphisms (SNPs) on pattern recognition receptor (PRR) such as toll-like receptors (TLRs), dendritic cell-associated C-type lectin-1 (Dectin-1/CLEC7A) genes of patients with invasive fungal infections (IFIs) caused by Candida and Aspergillus. We screened TLR4, Dectin-1 and PTX3 polymorphisms in a Turkish population with invasive aspergillosis (IA) underlying haematological malignancies.