Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity


Saribas G. S. , Erdogan D., Goktas G., Akyol S. N. , HIRFANOĞLU İ. M. , GÜRGEN S. G. , ...Daha Fazla

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, cilt.36, sa.8, ss.1086-1092, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Konu: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1080/01443615.2016.1209174
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Sayfa Sayıları: ss.1086-1092

Özet

The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin.