Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity

Saribas G. S., Erdogan D., Goktas G., Akyol S. N., HIRFANOĞLU İ. M., GÜRGEN S. G., ...Daha Fazla

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, cilt.36, sa.8, ss.1086-1092, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1080/01443615.2016.1209174
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1086-1092
  • Anahtar Kelimeler: Cisplatin, acetyl l-carnitine, apoptosis, uterine tube, ANTIOXIDANT ENZYMES, RATS, DAMAGE, NEPHROTOXICITY, CHEMOTHERAPY, MECHANISMS, APOPTOSIS, ESTER, LIVER
  • Gazi Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin.