Double aneuploidy in spontaneous miscarriages: Two case reports and review of the literature


Korucuoglu U., ERDEM M., Pala E., YİRMİBEŞ KARAOĞUZ M., ERDEM A., Biri A.

FETAL DIAGNOSIS AND THERAPY, vol.24, no.2, pp.106-110, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 24 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1159/000142138
  • Journal Name: FETAL DIAGNOSIS AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.106-110
  • Gazi University Affiliated: Yes

Abstract

The occurrence of double aneuploidy is a relatively rare phenomenon. The clinical presentations are variable depending on the predominating aneuploidy or a combination effect of both. We report the cytogenetic data on products of conception from miscarriages over a period of 5 years. A total of 403 miscarriages were karyotyped and the tissues were villi in all cases. Of 403 cases, 54 cases with single aneuploidy and 2 cases of first-trimester miscarriages with double trisomies were found. These 2 cases with the karyotypes of 48, XXY,+15 and 48, XX,+ 5,+ 7 were cited for the first time in this study. Copyright (C) 2008 S. Karger AG, Basel.