Chronic daily cortical spreading depressions suppress spreading depression susceptibility

Sukhotinsky I., Dilekoz E., Wang Y., Qin T., Eikermann-Haerter K., Waeber C., ...More

CEPHALALGIA, vol.31, no.16, pp.1601-1608, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 16
  • Publication Date: 2011
  • Doi Number: 10.1177/0333102411425865
  • Journal Name: CEPHALALGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1601-1608
  • Keywords: Spreading depression, chronic migraine, astrocyte, MIGRAINE, SPECTRUM, MOUSE, CLASSIFICATION, ASTROCYTES, GLUTAMATE, HEADACHE, INJURY, ONSET, MICE
  • Gazi University Affiliated: Yes

Abstract

Background: Migraine is a disabling chronic episodic disorder. Attack frequency progressively increases in some patients. Incremental cortical excitability has been implicated as a mechanism underlying progression. Cortical spreading depression (CSD) is the electrophysiological event underlying migraine aura, and a headache trigger. We hypothesized that CSD events during frequent migraine attacks condition the cortex to increase the susceptibility to further attacks.