Prevalence of MTHFR, MTR and MTRR gene polymorphisms in Turkish patients with nonsyndromic cleft lip and palate

Aşlar D., TAŞTAN H.

Gene Therapy and Molecular Biology, cilt.16, sa.1, ss.115-129, 2014 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2014
  • Dergi Adı: Gene Therapy and Molecular Biology
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.115-129
  • Anahtar Kelimeler: Cleft lip, Cleft palate, MTHFR, Polymorphism
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: To assess the association between the MTHFR gene (Al298C), MTR gene (A2756G) and MTRR gene (A66G) polymorphisms and nonsyndromic cleft lip with or without cleft palate(nsCL/P), we investigated patients in the Turkish population. Methodology: Analysis of gene polymorphisms was carried out using polymerase chain reactions and restriction enzyme digestions. Our study included 100 patients with nsCL/P and 125 age matched healty individuals. Results: We found that MTHFR Al298C polymorphism and MTR A2756G polymorphism are significant risk factors for nsCL/P. The frequency of MTRR A66G homozygotes was higher compared to control group, however the difference was not statistically significant. Conclusions: We revealed a statistical significant association between the MTHFR Al298C and MTR A2756G polymorphism and nsCL/P.