Plasma leptin, neuropeptide Y, ghrelin, and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate

Tokgoz H., Aydin K., ORAN B., Kiyici A.

CHILDS NERVOUS SYSTEM, cilt.28, sa.7, ss.1049-1053, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 7
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00381-012-1788-7
  • Dergi Adı: CHILDS NERVOUS SYSTEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1049-1053
  • Anahtar Kelimeler: Adiponectin, Carotid artery intima media thickness, Epilepsy, Ghrelin, Leptin, Neuropeptide Y, Valproate, WEIGHT-GAIN, SERUM-INSULIN, ACID, OBESITY, ATHEROSCLEROSIS, MONOTHERAPY, EXPRESSION, BODYWEIGHT
  • Gazi Üniversitesi Adresli: Evet

Özet

Weight gain is a common side effect of valproate (VPA) treatment, although the mechanism is not clear. Abnormal weight gain and obesity are associated with dyslipidemia, hypertension, and atherosclerosis. Measurement of the common carotid artery intima media thickness (CAIMT) gives a picture of early arterial wall alterations and, currently, is considered a noninvasive marker of premature atherosclerosis. The aim of the present study was to evaluate plasma insulin, leptin, neuropeptide Y (NPY), ghrelin, and adiponectin levels in children with epilepsy treated with VPA and to evaluate these parameters for early atherosclerosis.