Plasma leptin, neuropeptide Y, ghrelin, and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate

Tokgoz H., Aydin K., ORAN B., Kiyici A.

CHILDS NERVOUS SYSTEM, vol.28, no.7, pp.1049-1053, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 7
  • Publication Date: 2012
  • Doi Number: 10.1007/s00381-012-1788-7
  • Journal Name: CHILDS NERVOUS SYSTEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1049-1053
  • Keywords: Adiponectin, Carotid artery intima media thickness, Epilepsy, Ghrelin, Leptin, Neuropeptide Y, Valproate, WEIGHT-GAIN, SERUM-INSULIN, ACID, OBESITY, ATHEROSCLEROSIS, MONOTHERAPY, EXPRESSION, BODYWEIGHT
  • Gazi University Affiliated: Yes

Abstract

Weight gain is a common side effect of valproate (VPA) treatment, although the mechanism is not clear. Abnormal weight gain and obesity are associated with dyslipidemia, hypertension, and atherosclerosis. Measurement of the common carotid artery intima media thickness (CAIMT) gives a picture of early arterial wall alterations and, currently, is considered a noninvasive marker of premature atherosclerosis. The aim of the present study was to evaluate plasma insulin, leptin, neuropeptide Y (NPY), ghrelin, and adiponectin levels in children with epilepsy treated with VPA and to evaluate these parameters for early atherosclerosis.