Angiotensin-Converting Enzyme Inhibitor Reduces Radiation-Induced Periprosthetic Capsular Fibrosis

Erpolat, ÖZGE; Senturk, MUHAMMED; Saribas, Sanem; Pasinlioglu, Burak; Gulbahar, ÖZLEM; Tuncer, Serhan; Demircan, Volkan; Catli Dinc, SERAP; Polat, Omer; Elmas, ÇİĞDEM

doi:10.1016/j.jss.2021.01.033

Angiotensin-Converting Enzyme Inhibitor Reduces Radiation-Induced Periprosthetic Capsular Fibrosis

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Erpolat Ö. P., Senturk E., Saribas S., Pasinlioglu B., Gulbahar Ö., Tuncer S., ...More

JOURNAL OF SURGICAL RESEARCH, vol.263, pp.167-175, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 263
Publication Date: 2021
Doi Number: 10.1016/j.jss.2021.01.033
Journal Name: JOURNAL OF SURGICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
Page Numbers: pp.167-175
Keywords: Silicone capsule, Radiation, ACE inhibitor, Ramipril, Fibrosis, Contracture, BREAST-CANCER PATIENTS, MATRIX METALLOPROTEINASES, TISSUE INHIBITORS, MURINE MODEL, TGF-BETA-1, RECONSTRUCTION, RADIOTHERAPY, CONTRACTURE, CYTOKINES, IMPLANTS
Gazi University Affiliated: Yes

Abstract

Background: The capsular contracture is one of the main complications after radiotherapy in patients with implant-based reconstruction. The aim of this study is to evaluate the efficacy of ramipril for the prevention of radiation-induced fibrosis around the silicone implant.