Active vitamin D is cardioprotective in experimental uraemia but not in children with CKD Stages 3-5

Schoen A., Leifheit-Nestler M., Deppe J., Fischer D., KARABAY BAYAZIT A., Obrycki L., ...Daha Fazla

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.36, sa.3, ss.442-451, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1093/ndt/gfaa227
  • Dergi Adı: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.442-451
  • Anahtar Kelimeler: chronic kidney disease, fibroblast growth factor 23, left ventricular hypertrophy, renin-angiotensin system, vitamin D, LEFT-VENTRICULAR HYPERTROPHY, CHRONIC KIDNEY-DISEASE, GROWTH-FACTOR 23, CARDIAC-HYPERTROPHY, D THERAPY, KLOTHO, PARICALCITOL, CALCIUM, FIBROBLAST-GROWTH-FACTOR-23, PROGRESSION
  • Gazi Üniversitesi Adresli: Evet

Özet

Background. Uraemic cardiac remodelling is associated with vitamin D and Klotho deficiency, elevated fibroblast growth factor 23 (FGF23) and activation of the renin-angiotensin system (RAS). The cardioprotective properties of active vitamin D analogues in this setting are unclear.