Vaccination status of COVID-19 patients followed up in the ICU in a country with heterologous vaccination policy: A multicenter national study in Turkey

Yıldırım, Süleyman; Erkoyun, Erdem; Alpdoğan, Özcan; Yılmaz, Hüseyin; Yılmaz, Barış; Erdal Dönmez, Gül; Sarıtaş, Aykut; GÖKMEN, ALİ; ERGAN, BEGÜM; Bayrak, Vecihe; Yakar, Mehmet; Kılıç, Özgür; Kılınç, Ahmet; Saygılı, Saba; Gaygısız, ÜMMÜGÜLSÜM; Aydın, Kaniye; Özel Yeşilyurt, Aysun; Cankar Dal, Hayriye; Bayındır Dicle, Çilem; Turan, Sema; Binay, Songül; Yarıcı, Metin; Yıldırım, Fatma; Hancı, Pervin; İnal, Mehmet; Akbaş, Türkay; Eyüpoğlu, Selin; Albayrak, Tuna; Koçak, Gamze; Çakır, Tümay; Yüksel, Recep; Sarı, Ali; Güneş, Murat; Menteş, Oral; Yamanel, H.; Kirakli, Cenk

doi:10.1016/j.jiac.2023.06.012

Vaccination status of COVID-19 patients followed up in the ICU in a country with heterologous vaccination policy: A multicenter national study in Turkey

Atıf İçin Kopyala

Yıldırım S., Erkoyun E., Alpdoğan Ö., Yılmaz H. O., Yılmaz B., Erdal Dönmez G., ...Daha Fazla

Journal of Infection and Chemotherapy, cilt.29, sa.10, ss.959-964, 2023 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29 Sayı: 10
Basım Tarihi: 2023
Doi Numarası: 10.1016/j.jiac.2023.06.012
Dergi Adı: Journal of Infection and Chemotherapy
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.959-964
Anahtar Kelimeler: COVID-19, Intensive care unit, Mortality, Vaccination
Gazi Üniversitesi Adresli: Evet

Özet

Objective: Vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-2) prevents the development of serious diseases has been shown in many studies. However, the effect of vaccination on outcomes in COVID-19 patients requiring intensive care is not clear. Methods: This is a retrospective multicenter study conducted in 17 intensive care unit (ICU) in Turkey between January 1, 2021, and December 31, 2021. Patients aged 18 years and older who were diagnosed with COVID-19 and followed in ICU were included in the study. Patients who have never been vaccinated and patients who have been vaccinated with a single dose were considered unvaccinated. Logistic regression models were fit for the two outcomes (28-day mortality and in-hospital mortality). Results: A total of 2968 patients were included final analysis. The most of patients followed in the ICU during the study period were unvaccinated (58.5%). Vaccinated patients were older, had higher Charlson comorbidity index (CCI), and had higher APACHE-2 scores than unvaccinated patients. Risk for 28-day mortality and in-hospital mortality was similar in across the year both vaccinated and unvaccinated patients. However, risk for in-hospital mortality and 28-day mortality was higher in the unvaccinated patients in quarter 4 adjusted for gender and CCI (OR: 1.45, 95% CI: 1.06–1.99 and OR: 1.42, 95% CI: 1.03–1.96, respectively) compared to the vaccinated group. Conclusion: Despite effective vaccination, fully vaccinated patients may be admitted to ICU because of disease severity. Unvaccinated patients were younger and had fewer comorbid conditions. Unvaccinated patients have an increased risk of 28-day mortality when adjusted for gender and CCI.