Flavonoids targeting NRF2 in neurodegenerative disorders

Khan H., Tundis R., Ullah H., Aschner M., Belwal T., Mirzaei H., ...Daha Fazla

FOOD AND CHEMICAL TOXICOLOGY, cilt.146, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 146
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.fct.2020.111817
  • Dergi Adı: FOOD AND CHEMICAL TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Anahtar Kelimeler: Nrf2, Flavonoids, Neurodegenrative disorders, Neuroprotection, TRANSCRIPTION FACTOR NRF2, SIGNALING PATHWAY, PARKINSONS-DISEASE, THERAPEUTIC TARGET, OXIDATIVE STRESS, BARDOXOLONE METHYL, EMERGING ROLE, MOUSE MODEL, BETA-TRCP, ACTIVATION
  • Gazi Üniversitesi Adresli: Evet

Özet

Neurodegenerative disorders are characterized by progressive loss of neurons. To date, no efficacious therapies exist for these disorders, and current therapies provide only symptomatic relief. The neuroprotective effects of natural compounds have been reported in several neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) amyotrophic lateral sclerosis (ALS), cerebral ischemia and brain tumors. Flavonoids are the most widely studied natural products for the prevention and treatment of neurodegenerative disorders. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) represents a complex gene regulated cytoprotective pathway. Several natural compounds have been identified as Nrf2 regulators in various chronic disorders, including carcinogenic, liver ailments, inflammatory conditions, neurodegeneration, diabetes and cardiotoxicities. The current review focuses on Nrf2 targeting by flavonoids in the prevention and treatment of neurodegenerative disorders, addressing the most contemporary information available on this timely subject.