Synthesis, Characterization, Antimicrobial Activity Study of a Novel Salt of Dipicolinic Acid with 2-Amino-5-Methylpyridine and Their Metal Complexes

İlkimen H., Salün S., Gülbandýlar A., Sarý M.

Pharmaceutical Chemistry Journal, cilt.58, sa.12, ss.1821-1826, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 12
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s11094-025-03342-y
  • Dergi Adı: Pharmaceutical Chemistry Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core
  • Sayfa Sayıları: ss.1821-1826
  • Anahtar Kelimeler: 2,6-pyridinedicarboxylic acid, 2-amino-5-methylpyridine, antifungal and antibacterial activity, metal complex, proton transfer salt
  • Gazi Üniversitesi Adresli: Evet

Özet

A new salt (1), obtained from pyridine-2,6-dicarboxylic acid (H2dpc) with and 2-amino-5-methylpyridine (2a5mp) and Fe(II) (2), Fe(III) (3), Co(II) (4), Ni(II) (5), Cu(II) (6) complexes and Co(II) complex (7) of H2 dpc were prepared and elucidated via 1H and 13C NMR for 1, UV, FT-IR, molar conductivity, magnetic measurement and AAS for 1-7 and x-ray crystallography for 7. Furthermore, the antifungal and antibacterial properties of all the compounds were also tested against C. krusei, C. albicans, C. parapisilosis, E. faecalis, E. coli and S. aureus. The outcomes were contrasted with those obtained with Vancomycin, Fluconazole, Cefepime and Levofloxacin (standard agents).