Synthesis of some new 1-acylthiosemicarbazides and 1,2,4-triazol-5-thiones, and their analgesic and anti-inflammatory activities


Duendar Y., Cakir B., Kuepeli E., Sahin M. F., Noyanalpan N.

Turkish Journal of Chemistry, vol.31, no.3, pp.301-313, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2007
  • Journal Name: Turkish Journal of Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.301-313
  • Keywords: 2-benzothiazolinone, thiosemicarbazide, 1,2,4-triazol-5-thione, analgesic and anti-inflammatory activity, CYCLOOXYGENASE-2 INHIBITORS, ANTINOCICEPTIVE ACTIVITY, DERIVATIVES, AGENTS, 1,2,4-TRIAZOLE-3-THIONES, 1,3,4-THIADIAZOLES, 1,3,4-OXADIAZOLES, THIADIAZOLES, TRIAZOLES, DRUGS
  • Gazi University Affiliated: Yes

Abstract

We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4-substituted- thiosemicarbazides and their corresponding cyclized 3-[2-(2-oxobenzothiazoline- 3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione analogs in which position 4 of the triazole ring was substituted by cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl, p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their analgesic and anti-inflammatory activities as well as gastric ulceration potential in test animals. None of the compounds, except 5a, 5e, and 5h, caused gastric lesions or bleeding. Compound 5g was found to have higher analgesic and anti-inflammatory activity among the synthesized compounds. © TÜBİTAK.