Synthesis of some new 1-acylthiosemicarbazides and 1,2,4-triazol-5-thiones, and their analgesic and anti-inflammatory activities

Duendar Y., Cakir B., Kuepeli E., Sahin M. F., Noyanalpan N.

Turkish Journal of Chemistry, cilt.31, sa.3, ss.301-313, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 3
  • Basım Tarihi: 2007
  • Dergi Adı: Turkish Journal of Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.301-313
  • Anahtar Kelimeler: 2-benzothiazolinone, thiosemicarbazide, 1,2,4-triazol-5-thione, analgesic and anti-inflammatory activity, CYCLOOXYGENASE-2 INHIBITORS, ANTINOCICEPTIVE ACTIVITY, DERIVATIVES, AGENTS, 1,2,4-TRIAZOLE-3-THIONES, 1,3,4-THIADIAZOLES, 1,3,4-OXADIAZOLES, THIADIAZOLES, TRIAZOLES, DRUGS
  • Gazi Üniversitesi Adresli: Evet

Özet

We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4-substituted- thiosemicarbazides and their corresponding cyclized 3-[2-(2-oxobenzothiazoline- 3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione analogs in which position 4 of the triazole ring was substituted by cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl, p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their analgesic and anti-inflammatory activities as well as gastric ulceration potential in test animals. None of the compounds, except 5a, 5e, and 5h, caused gastric lesions or bleeding. Compound 5g was found to have higher analgesic and anti-inflammatory activity among the synthesized compounds. © TÜBİTAK.