With the rapid digitalization effect experienced recently,new technologies have been developed for systems, where,system design has also taken its share from this rapidchange. Due to the strong relationship between employeewelfare and industrial system productivity, there is anincreasing interest in ergonomics and human factorsengineering fields in Industrial Engineering literature. Inorder to implement Industry 4.0 applications in worksystems and adapt the job design, scientific researchersand managers are integrating the traditional point ofview and developing new technology for the evaluation ofrisk factors as well as realization of ergonomicregulations, while at the same time suggestinginterventions to balance and reduce the physicalergonomic risk existing in the current system. approachesshould be developed. In this study, the use of collaborativerobot (Cobot) technologies for system design that willincrease the ergonomic suitability of the work system andworkplace by reducing the level of physical risk in jobdesign during the transformation to smart factory andsmart production areas as Industry 4.0 componenta isdiscussed. In the study, a suitability scale was developedfor the applications to be realized in human-robotinteractive production lines by investigating the factorsthat should be considered in the selection of theworkstation to which the Cobot technology will beassigned.With the rapid digitalization effect experienced recently, new technologies have been developed for systems, where, system design has also taken its share from this rapid change. Due to the strong relationship between employee welfare and industrial system productivity, there is an increasing interest in ergonomics and human factors engineering fields in Industrial Engineering literature. In order to implement Industry 4.0 applications in work systems and adapt the job design, scientific researchers and managers are integrating the traditional point of view and developing new technology for the evaluation of risk factors as well as realization of ergonomic regulations, while at the same time suggesting interventions to balance and reduce the physical ergonomic risk existing in the current system. approaches should be developed. In this study, the use of collaborative robot (Cobot) technologies for system design that will increase the ergonomic suitability of the work system and workplace by reducing the level of physical risk in job design during the transformation to smart factory and smart production areas as Industry 4.0 componenta is discussed. In the study, a suitability scale was developed for the applications to be realized in human-robot interactive production lines by investigating the factors that should be considered in the selection of the workstation to which the Cobot technology will be assigned.