This study investigates the mediating effects of psychological capital and trust on the individual performance and job satisfaction relationship by using bootstrapping method. We test our multiple mediation model with a sample of 260 medical staff, which is composed of doctors and nurses. The bootstrap estimates arc based on 5000 bootstrap samples in this study. Results reveal that psychological capital and trust transmit the effect of individual performance to job satisfaction. Both are found as mediators for the relationship between individual performance and job satisfaction. Some suggestions for future research will be offered.