Physicochemical Characterization and Hydrolytic Stability of TPMS-Architected Nerve Guide Conduits Fabricated by DLP 3D Printing
MACROMOLECULAR MATERIALS AND ENGINEERING, cilt.311, sa.7, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 311 Sayı: 7
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/mame.70281
- Dergi Adı: MACROMOLECULAR MATERIALS AND ENGINEERING
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Compendex, INSPEC, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Engineering Source (EBSCO), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Gazi Üniversitesi Adresli: Evet
Özet
In the literature, a limited number of studies have investigated the combined effects of electrical conductivity, swelling behavior, and degradation properties in Triple Periodic Minimal Surface (TPMS)-based nerve guidance conduits (NGCs). In this study, four TPMS geometries (Schwarz, Gyroid, Diamond, and Split-P) and one solid cylindrical geometry were produced via Digital Light Processing (DLP) and evaluated comparatively. Electrical measurements revealed that conductivity is largely dependent on the internal architecture. The solid cylinder exhibited the highest value (2.85 & times; 10- 4 S/cm), followed by Gyroid (2.80 & times; 10- 4 S/cm). The Diamond structure showed the lowest conductivity (1.53 & times; 10- 4 S/cm). Eight-week in vitro degradation tests revealed accelerated mass loss in porous TPMS structures; the Gyroid exhibited the highest degradation rate (96.16% remaining mass), while the Schwarz structure showed the highest mass retention rate (98.62%) among the TPMS designs. Compression tests confirmed that all TPMS-based channels maintained sufficient mechanical integrity under physiologically relevant loads. The findings demonstrate that the TPMS architecture provides an effective design parameter for customizing the electrical, mechanical, and degradation behavior of NGCs without altering the base material, suggesting potential for nerve regeneration applications.