The evaluation of thiol-disulfite balance, ischemia albumin modification and seruloplazmine as a new oxidative stress in mild cognitive impairment and early stage alzheimer's disease patients


Gunduztepe Y., BUKAN N., Zorlu E., Karaman Y., Topkan T. A. , Gurbuz N., ...More

JOURNAL OF CLINICAL NEUROSCIENCE, vol.75, pp.188-194, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jocn.2019.12.026
  • Journal Name: JOURNAL OF CLINICAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.188-194
  • Keywords: Alzheimer Disease, Oxidative stress, Thiol metabolism, Dynamic thiol- disulphide homeostasis, Ischemia-modified albumin (IMA), Ceruloplasmine, GROWTH-HORMONE, ASSAY, INFLAMMATION, ASSOCIATION, EXPRESSION, BRAIN, AGE, METAANALYSIS, GLUTATHIONE, HYPOTHESIS
  • Gazi University Affiliated: Yes

Abstract

Background: Alzheimer's Disease (AD) is the most common form of dementia seen in advanced age. It is characterized by progressive deterioration in cognitive functions. The prevalence of Alzheimer's disease increasing day by day due to the increase in the share of the elderly population in the general population due to developing health and living conditions, is limited and early diagnosis and effective treatment possibilities are very limited. From this point of view, a specific biomarker for AD is very important. As a new oxidative stress biomarker, the levels of thiol-disulfide balance, ischemia-modified albumin and seroloplazminin were evaluated. The aim of this study was to determine the serum levels of oxidative stress biomarkers in the early stages of the disease and to compare these oxidative stress markers with patients with mild cognitive impairment as a precursor form of Alzheimer's disease and to determine whether these markers develop at an earlier stage.