Expression of laminin receptor 1 in human placentas from normal and preeclamptic pregnancies and its relationship with the severity of preeclampsia

Kurdoglu M., KURDOĞLU Z., Ozen S., Kucukaydin Z., Bulut G., Erten R., ...Daha Fazla

JOURNAL OF PERINATAL MEDICINE, sa.4, ss.411-416, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1515/jpm.2011.024
  • Dergi Adı: JOURNAL OF PERINATAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.411-416
  • Anahtar Kelimeler: Immunohistochemistry, laminin receptor 1, placenta, preeclampsia
  • Gazi Üniversitesi Adresli: Hayır

Özet

Objectives: To investigate the expression of laminin receptor 1 (LR1), a non-integrin-type laminin receptor, in preeclamptic and normal third-trimester placentas, as well as to investigate whether its expression differs with disease severity. Study design: Third trimester placental samples obtained from deliveries of preeclamptic (n = 34) and normotensive healthy pregnant women (n = 35) were immunohistochemically studied for the expression of LR1. The placentas from both mild (n = 14) and severe (n = 20) preeclamptic pregnancies were further assessed for strength of LR1 expression according to disease severity. Results: When compared with normal placentas, the staining with LR1 protein in cytotrophoblasts and syncytiotrophoblasts was lower in preeclamptic placentas (P<0.05 and P<0.01, respectively). The intensity of staining with LR1 in decidual cells, cytotrophoblasts, syncytiotrophoblasts, and extracellular matrix cells of preeclamptic placentas did not vary with disease severity (P>0.05). Conclusions: Decreased LR1 expression in cytotrophoblasts and syncytiotrophoblasts of preeclamptic placentas, which may be independent of disease severity, might have a role in shallow trophoblastic invasion in preeclampsia.