DEVELOPMENT AND EVALUATION OF A BUCCOADHESIVE PROPRANOLOL TABLET FORMULATION


CELEBI N., KISLAL O.

PHARMAZIE, cilt.50, sa.7, ss.470-472, 1995 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Konu: 7
  • Basım Tarihi: 1995
  • Dergi Adı: PHARMAZIE
  • Sayfa Sayıları: ss.470-472

Özet

Buccoadhesive tablets were prepared by directly compressing propranolol with poly(acrylic)acid (PAA), hydroxypropylmethylcellulose (HPMC) and hydroxypropylcellulose (HPC) in different ratios. The release data were fitted to M(t)/M(proportional to) = kt(n) simple equation. The release characteristics has shown a non-Fickian mechanism of release. The best kinetic fit were zero order and slab erosion kinetic. The detachment force between buccoadhesive tablets and bovine buccal mucosa was carried out by the tensile tester apparatus. The high amount of PAA containing fomulation demonstrated the greatest adhesive force.