The effect of granulocyte macrophage-colony stimulating factor on glutathione and lipid peroxidation in a rat model

Kilic D., Sayan H., Gonul B., Egehan I.

EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, cilt.26, sa.7, ss.701-704, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 7
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1053/ejso.2000.0984
  • Dergi Adı: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.701-704
  • Gazi Üniversitesi Adresli: Hayır

Özet

Aims: Irradiation decreases incisional healing and produces oxygen radicals that damage cells. Because of the lipid component in the membrane, lipid peroxidation is reported to be particularly susceptible to radiation damage. Glutathione acts as a cosubstrate in the enzymatic repair of radiation damage. The aim of this study is to examine the role of granulocyte macrophage-colony stimulating factor (GM-CSF) in incisional skin wounds by investigating lipid peroxidation and reduced glutathione levels in the irradiated rats.