The effect of granulocyte macrophage-colony stimulating factor on glutathione and lipid peroxidation in a rat model


Kilic D., Sayan H., Gonul B., Egehan I.

EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, vol.26, no.7, pp.701-704, 2000 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 7
  • Publication Date: 2000
  • Doi Number: 10.1053/ejso.2000.0984
  • Journal Name: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.701-704

Abstract

Aims: Irradiation decreases incisional healing and produces oxygen radicals that damage cells. Because of the lipid component in the membrane, lipid peroxidation is reported to be particularly susceptible to radiation damage. Glutathione acts as a cosubstrate in the enzymatic repair of radiation damage. The aim of this study is to examine the role of granulocyte macrophage-colony stimulating factor (GM-CSF) in incisional skin wounds by investigating lipid peroxidation and reduced glutathione levels in the irradiated rats.