DNA binding studies with cis-dichlorobis (5(6)-non/chlorosubstituted-2-hydroxymethyl-benzimidazole) platinum(II) complexes


Gumus F., Algul O.

JOURNAL OF INORGANIC BIOCHEMISTRY, cilt.68, sa.1, ss.71-74, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 1
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1016/s0162-0134(97)00041-x
  • Dergi Adı: JOURNAL OF INORGANIC BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.71-74
  • Gazi Üniversitesi Adresli: Hayır

Özet

The DNA binding properties of two new platinum cent pounds, cis-[Pt(L)(2)Cl-2]. 2H(2)O where L is 5(6)-non/ chlorosubstincted-2-hydroxymethylbenzimidazole, were examined and compared with cisplatin. The platinum compounds (compounds I and II) were used to modify, DNA, which was then used in electrophoretic mobility shift assays with the high mobility group (HMG)-domain protein, HMG1. The DNA platinated with these compounds was specifically recognized by HMG1. It was concluded that the adducts formed by compounds I and II distort the DNA in a manner similar to cisplatin diadducts. (C) 1997 Elsevier Science Inc.