DNA binding studies with cis-dichlorobis (5(6)-non/chlorosubstituted-2-hydroxymethyl-benzimidazole) platinum(II) complexes


Gumus F., Algul O.

JOURNAL OF INORGANIC BIOCHEMISTRY, vol.68, no.1, pp.71-74, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 1
  • Publication Date: 1997
  • Doi Number: 10.1016/s0162-0134(97)00041-x
  • Title of Journal : JOURNAL OF INORGANIC BIOCHEMISTRY
  • Page Numbers: pp.71-74

Abstract

The DNA binding properties of two new platinum cent pounds, cis-[Pt(L)(2)Cl-2]. 2H(2)O where L is 5(6)-non/ chlorosubstincted-2-hydroxymethylbenzimidazole, were examined and compared with cisplatin. The platinum compounds (compounds I and II) were used to modify, DNA, which was then used in electrophoretic mobility shift assays with the high mobility group (HMG)-domain protein, HMG1. The DNA platinated with these compounds was specifically recognized by HMG1. It was concluded that the adducts formed by compounds I and II distort the DNA in a manner similar to cisplatin diadducts. (C) 1997 Elsevier Science Inc.