Synthesis and antimicrobial activity of N-[(alpha-methyl)benzylidene]-(3-substituted-1,2,4-triazol-5-yl-thio) acetohydrazides

Ersan S., Nacak S., Berkem R.

FARMACO, vol.53, no.12, pp.773-776, 1998 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 12
  • Publication Date: 1998
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.773-776
  • Gazi University Affiliated: Yes


In this study 18 new hydrazones have been synthesized by reacting ortho- or para-substituted acetophenones with (3-substituted-1,2,4-triazol-5-yl-thio)acetohydrazide in ethanol. The prepared compounds were tested for antimicrobial activity. The prepared compounds exhibited only poor activity against Gram (+) and Gram (-) bacteria with the minimal inhibitory concentration (MIC) greater than or equal to 400 mu g/ml. Moderate activity was observed against Candida species with MIC in the range 100-400 mu g/ml. (C) 1998 Elsevier Science S.A. All rights reserved.