Toxicological Evaluation of Bisphenol A and Its Analogues

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Iyigundogdu İ., ÜSTÜNDAĞ A., DUYDU Y.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.4, pp.457-462, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2019.58219
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.457-462
  • Keywords: Bisphenols, bisphenol A, endocrine disruptor, bisphenol S, bisphenol F, ALTERNATIVES, POTENTIALS, ZEBRAFISH, TOXICITY, EXPOSURE, DAMAGE, BPZ
  • Gazi University Affiliated: Yes


Bisphenol A (BPA) is known as one of the oldest synthetic compounds with endocrine disrupting activity. It is commonly used in the production of epoxy resins, polycarbonates, dental fillings, food storage containers, baby bottles, and water containers. BPA is associated with various health problems such as obesity, diabetes, chronic respiratory diseases, cardiovascular diseases, renal diseases, behavior disorders, breast cancer, tooth development disorders, and reproductive disorders. Increasing health concerns have led the industry to seek alternatives to BPA. As BPA is now being excluded from several consumer products, the use of alternative compounds is increasing. However, the chemicals used to replace BPA are also BP analogues and may have similar or higher toxicological effects on organisms. The aim of this review is to focus on the toxicological profiles of different BP analogues (i.e. BPS and BPF) which are increasingly used today as alternative to BPA.