Development of ketorolac tromethamine loaded biocompatible polymeric microspheres and matrix films: designing for topical application

Kaya S., Kondolot Solak E.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.72, sa.17, ss.1329-1339, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 17
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/00914037.2022.2097679
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.1329-1339
  • Anahtar Kelimeler: Controlled release, ketorolac tromethamine, microspheres, pain, poly (vinyl pyrrolidone), sodium carboxymethylcellulose, DRUG-DELIVERY SYSTEMS, CONTROLLED-RELEASE, CARBOXYMETHYL CELLULOSE, ETHYL CELLULOSE, BIODEGRADABLE MICROSPHERES, MUCOADHESIVE MICROSPHERES, INTRAVENOUS KETOROLAC, NETWORK MICROSPHERES, IN-VITRO, NANOPARTICLES
  • Gazi Üniversitesi Adresli: Evet

Özet

Ketorolac Tromethamine (KT) is a powerful and important active ingredient in the pyrropyrrole group of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). In this study, microspheres of sodium carboxymethylcellulose (NaCMC) and polyvinylpyrrolidone (PVP) were prepared by crosslinking with FeCl3. KT-loaded microspheres were coated with ethyl cellulose (EC) film to obtain transdermal patches. The cumulative release ranged between 22 and 82%. Moreover, equilibrium swelling values, entrapment efficiency, drug loading capacity, crosslinking density, and film thickness were examined. Microspheres and EC films were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and X-ray diffraction (XRD).