Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives


Creative Commons License

Akcay S., ÜLGER M., KAYNAK ONURDAĞ F., DÜNDAR Y.

ACTA CHIMICA SLOVENICA, cilt.65, ss.932-938, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 65 Konu: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.17344/acsi.2018.4590
  • Dergi Adı: ACTA CHIMICA SLOVENICA
  • Sayfa Sayıları: ss.932-938

Özet

In this study, new pyrido [3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl) pyrido [3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido [3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.