Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives

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Akcay S., Ülger M., Kaynak Onurdağ F., Dündar Y.

ACTA CHIMICA SLOVENICA, vol.65, no.4, pp.932-938, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.17344/acsi.2018.4590
  • Title of Journal : ACTA CHIMICA SLOVENICA
  • Page Numbers: pp.932-938


In this study, new pyrido [3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl) pyrido [3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido [3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.