The kynurenine pathway and role in mental health of post-COVID-19 patients.

Küçükkarapınar M., Karadağ R. F., Candansayar S.

Linking Neuroscience and Behavior in COVID-19, Rajkumar Rajendram,Victor R. Preedy,Vinood B. Patel and Colin R. Martin, Editör, Academic Press , London, ss.393-406, 2024

  • Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
  • Basım Tarihi: 2024
  • Yayınevi: Academic Press
  • Basıldığı Şehir: London
  • Sayfa Sayıları: ss.393-406
  • Editörler: Rajkumar Rajendram,Victor R. Preedy,Vinood B. Patel and Colin R. Martin, Editör
  • Gazi Üniversitesi Adresli: Evet

Özet

Summary points l Kynurenine, kynurenic acid, and nicotinic acid are elevated in COVID-19 patients, indicating activation of the immune regulatory enzyme indole 2,3-dioxygenase. l Metabolites of the tryptophan-kynurenine pathway (TKP) may be useful for monitoring the immune response and inflammatory status of COVID-19 patients. l The ratio of kynurenine to tryptophan increases during viral infection, which may lead to psychiatric disorders in COVID-19 patients. l TKP has been linked to cognitive impairment and neuropsychiatric symptoms in viral infections such as COVID-19. l Further research is needed to determine the precise mechanisms underlying the association between TKP metabolites and COVID-19-related neuropsychiatric symptoms. Therapeutic interventions targeting the TKP may potentially reduce the incidence and severity of neuropsychiatric symptoms in COVID-19 patients.