Thermodynamic analysis of the refrigeration systems is too complex because of thermodynamic properties equations of working fluids, involving the solution of complex differential equations. To simplify this complex process, this paper proposes a new approach (artificial neural network, ANN) to determine of thermodynamic properties of an environmentally friendly alternative refrigerant (R407c) for both saturated liquid-vapor region (wet vapor) and superheated vapor region. Instead of complex rules and mathematical routines, ANNs are able to learn the key information patterns within multidimensional information domain. Therefore, reducing the risk of experimental uncertainties and also removing the need for complex analytic equations requiring long computational time and efforts. R-2 values - which are errors known as absolute fraction of variance - in wet vapor region are 0.999706, 0.999949, 0.999909, 0.999988 and 0.999836 for specific volume, enthalpy, entropy, viscosity and thermal conductivity for training, respectively. Similarly, for superheated vapor, they are: 0.99992, 1, 0.99998, 0.99995 and 0.99996 for training data, respectively. Promising thermodynamics property results have been obtained for R407c within acceptable errors. PVTx properties predicted are in valid region for working conditions of the refrigeration systems in case of use to computer simulation programs. (c) 2008 Elsevier Ltd. All rights reserved.