Biomonitoring of bisphenol A, 4-nonylphenol, and 4-t-octylphenol in Turkish population: exposure and risk assessment.

Sukuroglu A. A., BATTAL D., Kocadal K., SUNGUR M. A., ÇOK İ., Unlusayin I.

Environmental science and pollution research international, cilt.29, sa.18, ss.26250-26262, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 18
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11356-021-17796-6
  • Dergi Adı: Environmental science and pollution research international
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, IBZ Online, ABI/INFORM, Aerospace Database, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Environment Index, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.26250-26262
  • Anahtar Kelimeler: Biomonitoring, Endocrine-disrupting chemical, Bisphenol A, 4-t-Octylphenol, 4-Nonylphenol, Turkish population, ENDOCRINE-DISRUPTING COMPOUNDS, SOLID-PHASE EXTRACTION, HUMAN URINE, ALKYLPHENOL ETHOXYLATES, NONYLPHENOL, METABOLITES, FATE, OCTYLPHENOL, WATER, BIOCONCENTRATION
  • Gazi Üniversitesi Adresli: Evet

Özet

Biomonitoring studies are important tools to understand the effects of endocrine-disrupting compounds on human health. Up to now, there have been no biomonitoring and risk assessment studies conducted in Turkish population in which urinary bisphenol A (BPA), 4-nonylphenol (4-NP), and 4-t-octylphenol (4-t-OP) levels were measured simultaneously. The aim of this study is to measure urinary BPA, 4-NP, and 4-t-OP on Turkish population and conduct a risk assessment using urinary levels of chemicals of interest. During the study, liquid chromatography with tandem mass spectrometry (LC-MS/MS) was used to measure urinary levels of above-mentioned chemicals, and human biomonitoring was used as a risk assessment tool in 103 volunteers, living in Mersin Region, Turkey. Urinary BPA, 4-NP, and 4-t-OP were founded as 0.0079 mu g/g creatinine, 0.0177 mu g/g creatinine, and 0.0114 mu g/g creatinine, respectively. The obtained estimated daily intakes (EDIs) were calculated as 0.095 mu g/kg bw/day, 0.041 mu g/kg bw/day, and 0.091 mu g/kg bw/day, for BPA, 4-NP, and 4-t-OP, respectively. In conclusion, although no potential health risk due to BPA and 4-NP exposure was observed, there might be health risks associated with 4-t-OP exposure in the Turkish population.