Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Syndrome Mutations Increase Susceptibility to Spreading Depression

Eikermann-Haerter K., Yuzawa I., Dilekoz E. , Joutel A., Moskowitz M. A. , Ayata C.

ANNALS OF NEUROLOGY, cilt.69, sa.2, ss.413-418, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Konu: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1002/ana.22281
  • Sayfa Sayıları: ss.413-418


Migraine with aura is often the first manifestation of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome (CADASIL), a disorder caused by NOTCH3 gene mutations expressed predominantly in vascular smooth muscle. Here, we report that cortical spreading depression (CSD), the electrophysiological substrate of migraine aura, is enhanced in mice expressing a vascular Notch 3 CADASIL mutation (R90C) or a Notch 3 knockout mutation. The phenotype was stronger in Notch 3 knockout mice, implicating both loss of function and neomorphic mutations in its pathogenesis. Our results link vascular smooth muscle Notch 3 mutations to enhanced spreading depression susceptibility, implicating the neurovascular unit in the development of migraine aura. ANN NEUROL 2011;69:413-418