Therapy-related refractory anemia with ringed sideroblasts in chronic lymphocytic leukemia: involvement of 3q21 region

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Yagci M., Sucak G., Ogur G., Haznedar R.

CANCER GENETICS AND CYTOGENETICS, vol.129, no.1, pp.43-46, 2001 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 129 Issue: 1
• Publication Date: 2001
• Doi Number: 10.1016/s0165-4608(01)00423-x
• Journal Name: CANCER GENETICS AND CYTOGENETICS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
• Page Numbers: pp.43-46
• Gazi University Affiliated: Yes

Abstract

Therapy-related myelodysplastic syndrome/acute myelogenous leukemia (t-MDS/AML) is extremely rare in chronic lymphocytic leukemia (CLL) despite extensive use of alkylating agents. We present a case of heavily treated CLL with resultant therapy-related refractory anemia with ringed sideroblasts (RARS). A complex cytogenetic abnormality including involvement of 3q21 was detected and to our knowledge, is the first report of a RARS case with a 3q21 abnormality. (C) 2001 Elsevier Science Inc. All rights reserved.