Therapy-related refractory anemia with ringed sideroblasts in chronic lymphocytic leukemia: involvement of 3q21 region

Yagci M., Sucak G., Ogur G., Haznedar R.

CANCER GENETICS AND CYTOGENETICS, vol.129, no.1, pp.43-46, 2001 (SCI-Expanded) identifier identifier identifier identifier


Therapy-related myelodysplastic syndrome/acute myelogenous leukemia (t-MDS/AML) is extremely rare in chronic lymphocytic leukemia (CLL) despite extensive use of alkylating agents. We present a case of heavily treated CLL with resultant therapy-related refractory anemia with ringed sideroblasts (RARS). A complex cytogenetic abnormality including involvement of 3q21 was detected and to our knowledge, is the first report of a RARS case with a 3q21 abnormality. (C) 2001 Elsevier Science Inc. All rights reserved.