The European research journal, vol.7, no.2, pp.127-135, 2021 (Refereed Journals of Other Institutions)
Objectives: The use of central venous catheters as hemodialysis (HD) vascular access is associated with worse
morbidity and mortality in HD patients. This occasion is often attributed to comorbidities of the patients with
central venous catheters. Studies reveal that a biofilm layer occurs on most of the tunneled-cuffed central
venous catheters (TC-CVCs). This study aimed to determine the oxidative stress (OS) and systemic
inflammation (SI) status in patients with TC-CVCs as HD vascular access without clinical signs and symptoms
Methods: The study is composed of eighty-five patients with a minimum HD vintage of one year. Patients
with a history of infection or a cardiovascular event within six months, malignancy, systemic inflammatory
diseases, or malnutrition were excluded. OS indices and SI markers were studied and compared in patients
with arteriovenous fistula (AVF) and TC-CVCs.
Results: Mean native thiol/total thiol (NT/TT) ratio was significantly higher and mean disulphide/total thiol
(DT/TT) ratio was significantly lower in AVF group comparing TC-CVC group (0.46 ± 0.17 and 0.36 ± 0.17,
p = 0.03 for NT/TT; 0.27 ± 0.08 and 0.31 ± 0.08, p = 0.04 for DS/TT; respectively). Mean OS index was
significantly lower in the AVF group comparing TC-CVC group (0.15 ± 0.14 and 0.24 ± 0.23, p = 0.04;
respectively]. Median hs-CRP levels and median IL-6 levels were significantly lower in AVF group comparing
TC-CVC group (5.8 [min: 3.0-max: 82.5] mg/L and 9.7 [min: 3.0-max: 45.4] mg/L, p = 0.004 for hs-CRP; 6.2
[min: 2.0-max:159.0] pg/mL and 12.2 [min: 2.6-max: 41.3) pg/mL, p = 0.01 for IL-6; respectively).
Conclusions: TC-CVCs inversely affect OS and systemic inflammatory status in HD patients, presumably
due to foreign body reactions and biofilm layers.
Keywords: Arteriovenous fistula, central venous catheters, hemodialysis vascular access, oxidative stress,