Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

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Akyol S., Ugurcu V., Altuntas A., Hasgul R., Cakmak O., Akyol O.

SCIENTIFIC WORLD JOURNAL, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume:
  • Publication Date: 2014
  • Doi Number: 10.1155/2014/561971
  • Journal Indexes: Science Citation Index Expanded, Scopus


Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.