Development of sustained release formulation of an antithrombotic drug and application of fuzzy logic

Tan C., Degim I. T.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, cilt.17, sa.2, ss.242-250, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3109/10837450.2010.531739
  • Dergi Adı: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.242-250
  • Anahtar Kelimeler: Clopidogrel, sustained release, antithrombotic drug, modelling, fuzzy logic, artificial neural network modelling, ARTIFICIAL NEURAL-NETWORK, CLOPIDOGREL, PHARMACOKINETICS, ANTIPLATELET, OPTIMIZATION, PHARMACOLOGY
  • Gazi Üniversitesi Adresli: Evet

Özet

Clopidogrel bisulphate has quite low bioavailability (40-50%). It was aimed to increase its bioavailability by designing a controlled release dosage form of clopidogrel, which is different from available current dosage forms in the market. There are also some attempts to overcome patent protection of clopidogrel by combination of active substances or preparation of controlled release tablets. Therefore, it was also aimed to determine in vitro and in vivo properties of controlled release clopidogrel tablets. The amounts of releases from formulations were subjected computer program and effects of components in the formulation on release were investigated (INFORM v. 3.7 and FORMRULES, Intelligensys Ltd). Two sustained release formulations and innovator product were selected and their effectiveness was compared by in vivo tests in rabbits. In conclusion, proposed controlled release formulations were found to be an alternative and to be more effective for longer periods than the commercial one.