Determination of terbutaline based on oxidation by voltammetry

Yilmaz N., Ozkan S., Uslu B., Senturk Z., Biryol I.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.17, sa.2, ss.349-355, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0731-7085(97)00226-4
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.349-355
  • Anahtar Kelimeler: terbutaline, voltammetry, activated glassy carbon electrode, formulation analysis, PERFORMANCE LIQUID-CHROMATOGRAPHY, CAPILLARY ZONE ELECTROPHORESIS, PHARMACEUTICAL DOSAGE FORMS, GLASSY-CARBON ELECTRODE, ELECTROCHEMICAL DETECTION, HUMAN PLASMA, SALBUTAMOL, FENOTEROL, ISOTACHOPHORESIS, SULFATE
  • Gazi Üniversitesi Adresli: Hayır

Özet

A voltammetric study of the oxidation of terbutaline has been carried out at an activated glassy carbon electrode. The compound was oxidized irreversibly at high positive potential. The response was evaluated with respect to pH, scan rate, nature of the buffer and other variables. The peak current, at about 0.8 V (versus a saturated calomel electrode), was proportional to the terbutaline concentration in the range of 8 x 10(-6)-8 x 10(-4) M in phosphate buffer pH 6.0. This method was applied, without any interferences from the excipients, to determine the drug in a tablet dosage form. (C) 1998 Elsevier Science B.V. All rights reserved.