Determination of terbutaline based on oxidation by voltammetry


Yilmaz N., Ozkan S., Uslu B., Senturk Z., Biryol I.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol.17, no.2, pp.349-355, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 1998
  • Doi Number: 10.1016/s0731-7085(97)00226-4
  • Journal Name: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.349-355
  • Keywords: terbutaline, voltammetry, activated glassy carbon electrode, formulation analysis, PERFORMANCE LIQUID-CHROMATOGRAPHY, CAPILLARY ZONE ELECTROPHORESIS, PHARMACEUTICAL DOSAGE FORMS, GLASSY-CARBON ELECTRODE, ELECTROCHEMICAL DETECTION, HUMAN PLASMA, SALBUTAMOL, FENOTEROL, ISOTACHOPHORESIS, SULFATE
  • Gazi University Affiliated: No

Abstract

A voltammetric study of the oxidation of terbutaline has been carried out at an activated glassy carbon electrode. The compound was oxidized irreversibly at high positive potential. The response was evaluated with respect to pH, scan rate, nature of the buffer and other variables. The peak current, at about 0.8 V (versus a saturated calomel electrode), was proportional to the terbutaline concentration in the range of 8 x 10(-6)-8 x 10(-4) M in phosphate buffer pH 6.0. This method was applied, without any interferences from the excipients, to determine the drug in a tablet dosage form. (C) 1998 Elsevier Science B.V. All rights reserved.