Alkaloids of Sternbergia clusiana and their analgesic effects

Tanker M., Citoglu G., Gumusel B., Sener B.

INTERNATIONAL JOURNAL OF PHARMACOGNOSY, vol.34, no.3, pp.194-197, 1996 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 1996
  • Doi Number: 10.1076/phbi.
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.194-197
  • Keywords: analgesic activity, lycorine, haemanthidine, modified Koster's test, Amaryllidaceae, Sternbergia clusiana (Ker-Gawl) Ker Gawl. ex Sprengel, AMARYLLIDACEAE, CONSTITUENTS
  • Gazi University Affiliated: No


Sternbergia clusiana of Turkish origin has yielded four alkaloids, lycorine, haemanthamine, haemanthidine, and tazettine. The alkaloids were separated using chromatographic methods and purified by crystallization. Their structures have been elucidated by spectroscopic studies. The analgesic activity of lycorine and haemanthidine was determined using modified Koster's test. Lycorine and haemanthidine showed a significant analgesic effect. The analgesic activities of lycorine and haemanthidine are higher than those of aspirin.