pH-Metric log K calculations of famotidine, naproxen, nizatidine, ranitidine and salicylic acid

Degim T., Zaimoglu V., Akay C., Degim Z.

FARMACO, vol.56, no.9, pp.659-663, 2001 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 9
  • Publication Date: 2001
  • Doi Number: 10.1016/s0014-827x(01)01114-4
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.659-663
  • Keywords: octanol/water partition coefficient, pH-metric log K calculations, famotidine, naproxen, nizatidine, ranitidine, salicylic acid, PARTITION-COEFFICIENTS, IONIZATION-CONSTANTS


The octanol/water partition coefficient (log K) is one of the most commonly used parameters in structure-activity relationships in many areas such as drug design (including pesticides), pharmacokinetics, anesthesiology, environmental sciences, toxicology, bioaccumulation and predicting skin permeability as a predictive parameter.