High expression of nuclear survivin and Aurora B predicts poor overall survival in patients with head and neck squamous cell cancer.

Erpolat Ö. P., Gocun P. U., Akmansu M., Karakus E., Akyol G.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], vol.188, no.3, pp.248-54, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 188 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1007/s00066-011-0042-7
  • Journal Name: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.248-54
  • Keywords: Survivin protein, human, Aurora B kinase, Squamous cell carcinoma of the head and neck, Radiotherapy, Biomarkers, MITOTIC KINASE, MOLECULAR-MECHANISM, APOPTOSIS, CARCINOMA, PROGNOSIS, INHIBITORS, THERAPY, INCENP, GENE
  • Gazi University Affiliated: Yes

Abstract

Background and purpose. Survivin is one of the apoptosis inhibitor proteins. Together with Aurora B, it also plays a role in regulating several aspects of mitosis. High expression of these markers is correlated with malignant behavior of various cancers and resistance to therapy. Our aim was to evaluate the prognostic role of these markers in head and neck cancers.